|
KMID : 0385020030190040261
|
|
Korean Journal of Laboratory Animal Science
2003 Volume.19 No. 4 p.261 ~ p.266
|
|
|
Establishment on Mumo-hairless Mouse Derived from ENU Mutagenesis
|
|
Nam Yoon-Yi
Cho Jae-Woo
Cho Kyu-Hyuk
Yoon Seok-Joo
Oh Yang-Seok
Sur Jun-Gyo
Han Sang-Seop
Song Chang-Woo
|
|
|
Abstract
|
|
|
|
ENU (N-ethyl-N-nitrosourea) mutagenesis can produce various mutant mice as human disease models. Total 200 mg/kg ENU was injected into peritoneum of male BALB/c at ten weeks of age with 100 mg/kg ENU at a weekly interval. In the 3rd generation, we could discovered phenodeviants with hair defect. This mutant mouse was distinguished from normal littermates at 21 days of age. The adult mutant showed total alopecia, wrinkled skin and curved long nails. We tentatively named the mutant as Mumo-hairless mouse. In carrrier and carrier matings, the incidence rates was 21% in the observed 52 mice until the 4th generation. The sex ratio of mutants was not significantly different. Thus this mouse was inherited by an autosomal recessive trait. Histologically, affected skin developed piliary cysts, deep dermal cysts, and decreased number of hair follicle of vibrissae compared with control mice. Taken together, candidate mouse is supposed be rhino mouse from their similar phenotype. Therefore, Mumo-hairless mice could be used as a model for human skin disease such as papular atrichia.
|
|
|
KEYWORD
|
|
|
ENU-mutagenesis, Hairless, Rhino mutation, Papular atrichia, Disease animal model
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|